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Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?
Eukaryotic initiation factor eIF2 is a key component of the ternary complex whose role is to deliver initiator tRNA into the ribosome. A variety of stimuli, both physiologic and pathophysiologic activate eIF2 kinases that phosphorylate the α subunit of eIF2, preventing it from forming the ternary co...
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| Publicado no: | Front Oncol |
|---|---|
| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4659918/ https://ncbi.nlm.nih.gov/pubmed/26636041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00264 |
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