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Natural Product Inspired Hsp90 N-Terminal Inhibitors for the Treatment of Cancer: From Bench to Bedside

The 90 kDa heat shock proteins (Hsp90) are responsible for the conformational maturation of nascent polypeptides and the rematuration of denatured proteins. Proteins dependent upon Hsp90 are associated with all six hallmarks of cancer. Upon Hsp90 inhibition, protein substrates are degraded via the u...

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Detalhes bibliográficos
Publicado no:Med Res Rev
Main Authors: Khandelwal, Anuj, Crowley, Vincent M., Blagg, Brian S. J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659773/
https://ncbi.nlm.nih.gov/pubmed/26010985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/med.21351
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