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Towards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational Dynamics
Due to its inhibition of the Abl kinase domain in the BCR-ABL fusion protein, imatinib is strikingly effective in the initial stage of chronic myeloid leukemia with more than 90% of the patients showing complete remission. However, as in the case of most targeted anti-cancer therapies, the emergence...
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| Publié dans: | PLoS Comput Biol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4659586/ https://ncbi.nlm.nih.gov/pubmed/26606374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004578 |
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