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Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG repeats at the ALS/FTD C9orf72 locus
A GGGGCC expansion within an intronic region of the C9orf72 gene forms RNA foci that are associated with one third of familial amyotrophic lateral sclerosis (ALS) and one quarter of frontotemporal dementia (FTD). The C9orf72 locus also expresses an antisense transcript with a CCCCGG expansion that f...
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| Publicado no: | Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4659491/ https://ncbi.nlm.nih.gov/pubmed/26584779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.09.016 |
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