Improvement of the Targeting of Radiolabeled and Functionalized Liposomes with a Two-Step System Using a Bispecific Monoclonal Antibody (Anti-CEA × Anti-DTPA–In)

This study proposes liposomes as a new tool for pretargeted radioimmunotherapy (RIT) in solid tumors. Tumor pretargeting is obtained by using a bispecific monoclonal antibody [BsmAb, anti-CEA × anti-DTPA-indium complex (DTPA–In)] and pegylated radioactive liposomes containing a lipid-hapten conjugat...

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Udgivet i:Front Med (Lausanne)
Main Authors: Rauscher, Aurore, Frindel, Mathieu, Rajerison, Holisoa, Gouard, Sébastien, Maurel, Catherine, Barbet, Jacques, Faivre-Chauvet, Alain, Mougin-Degraef, Marie
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658472/
https://ncbi.nlm.nih.gov/pubmed/26636087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmed.2015.00083
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