Subacute Nicotine Co-exposure Has No Effect on 2,2′,3,5′,6-Pentachlorobiphenyl Disposition But Alters Hepatic Cytochrome P450 Expression in the Male Rat

Polychlorinated biphenyls (PCBs) are metabolized by cytochrome P450 2B enzymes (CYP2B) and nicotine is reported to alter CYP2B activity in the brain and liver. To test the hypothesis that nicotine influences PCB disposition, 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) and its metabolites were quantifie...

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Bibliographic Details
Published in:Toxicology
Main Authors: Stamou, Marianna, Uwimana, Eric, Flannery, Brenna M., Kania-Korwel, Izabela, Lehmler, Hans-Joachim, Lein, Pamela J.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658283/
https://ncbi.nlm.nih.gov/pubmed/26463278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2015.10.002
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