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Subacute Nicotine Co-exposure Has No Effect on 2,2′,3,5′,6-Pentachlorobiphenyl Disposition But Alters Hepatic Cytochrome P450 Expression in the Male Rat
Polychlorinated biphenyls (PCBs) are metabolized by cytochrome P450 2B enzymes (CYP2B) and nicotine is reported to alter CYP2B activity in the brain and liver. To test the hypothesis that nicotine influences PCB disposition, 2,2′,3,5′,6-pentachlorobiphenyl (PCB 95) and its metabolites were quantifie...
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| Publicado no: | Toxicology |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4658283/ https://ncbi.nlm.nih.gov/pubmed/26463278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2015.10.002 |
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