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High-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia

To examine the T cell receptor structure in the absence of B cells, the TCR β CDR3 was sequenced from DNA of 15 X-linked agammaglobulinemia (XLA) subjects and 18 male controls, using the Illumina HiSeq platform and the ImmunoSEQ analyzer. V gene usage and the V–J combinations, derived from both prod...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Clin Immunol
Egile Nagusiak: Ramesh, Manish, Simchoni, Noa, Hamm, David, Cunningham-Rundles, Charlotte
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4658265/
https://ncbi.nlm.nih.gov/pubmed/26360253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.09.002
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