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High-throughput sequencing reveals an altered T cell repertoire in X-linked agammaglobulinemia
To examine the T cell receptor structure in the absence of B cells, the TCR β CDR3 was sequenced from DNA of 15 X-linked agammaglobulinemia (XLA) subjects and 18 male controls, using the Illumina HiSeq platform and the ImmunoSEQ analyzer. V gene usage and the V–J combinations, derived from both prod...
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| Published in: | Clin Immunol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4658265/ https://ncbi.nlm.nih.gov/pubmed/26360253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2015.09.002 |
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