ABCC8 R1420H Loss-of-Function Variant in a Southwest American Indian Community: Association With Increased Birth Weight and Doubled Risk of Type 2 Diabetes

Missense variants in KCNJ11 and ABCC8, which encode the KIR6.2 and SUR1 subunits of the β-cell K(ATP) channel, have previously been implicated in type 2 diabetes, neonatal diabetes, and hyperinsulinemic hypoglycemia of infancy (HHI). To determine whether variation in these genes affects risk for typ...

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Vydáno v:Diabetes
Hlavní autoři: Baier, Leslie J., Muller, Yunhua Li, Remedi, Maria Sara, Traurig, Michael, Piaggi, Paolo, Wiessner, Gregory, Huang, Ke, Stacy, Alyssa, Kobes, Sayuko, Krakoff, Jonathan, Bennett, Peter H., Nelson, Robert G., Knowler, William C., Hanson, Robert L., Nichols, Colin G., Bogardus, Clifton
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2015
Témata:
Genetics/Genomes/Proteomics/Metabolomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657583/
https://ncbi.nlm.nih.gov/pubmed/26246406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-0459
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