Transcription factor Bcl11b controls identity and function of mature innate lymphoid cells type II

Type-2 innate lymphoid cells (ILC2s) promote anti-helminth responses and contribute to allergies. Here we report that Bcl11b, previously considered a T-cell lineage identity transcription factor, acts directly upstream of the key ILC2 transcription factor Gfi1 to maintain its expression in mature IL...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Califano, Danielle, Cho, Jonathan J., Uddin, Mohammad N., Lorentsen, Kyle J., Yang, Qi, Bhandoola, Avinash, Li, Hongmin, Avram, Dorina
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657441/
https://ncbi.nlm.nih.gov/pubmed/26231117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.07.005
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