Bcl11b prevents fatal autoimmunity by promoting T(reg) cell program and constraining innate lineages in T(reg) cells

Regulatory T (T(reg)) cells are essential for peripheral tolerance and rely on the transcription factor (TF) Foxp3 for their generation and function. Several other TFs are critical for the T(reg) cell program. We found that mice deficient in Bcl11b TF solely in T(reg) cells developed fatal autoimmun...

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Vydáno v:Sci Adv
Hlavní autoři: Drashansky, Theodore T., Helm, Eric, Huo, Zhiguang, Curkovic, Nina, Kumar, Preet, Luo, Xiaoping, Parthasarathy, Upasana, Zuniga, Ashley, Cho, Jonathan J., Lorentsen, Kyle J., Xu, Zhiwei, Uddin, Mohammad, Moshkani, Safiehkhathoon, Zhou, Liang, Avram, Dorina
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6685710/
https://ncbi.nlm.nih.gov/pubmed/31457080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw0480
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