The coactivator PGC-1α regulates mouse skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet

AIMS/HYPOTHESIS: Physical activity improves oxidative capacity and exerts therapeutic beneficial effects, particularly in the context of metabolic diseases. The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) and the nuclear receptor PPARβ/δ have both been independently...

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Publicado en:Diabetologia
Autores principales: Pérez-Schindler, Joaquín, Svensson, Kristoffer, Vargas-Fernández, Elyzabeth, Santos, Gesa, Wahli, Walter, Handschin, Christoph
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4657154/
https://ncbi.nlm.nih.gov/pubmed/25116175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3352-3
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