Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα

BACKGROUND: Platelets are essential for maintaining haemostasis and play a key role in the pathogenesis of cardiovascular disease. Upon ligation of platelet receptors through subendothelial matrix proteins, intracellular reactive oxygen species (ROS) are generated, further amplifying the platelet ac...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Carrim, Naadiya, Arthur, Jane F., Hamilton, Justin R., Gardiner, Elizabeth E., Andrews, Robert K., Moran, Niamh, Berndt, Michael C., Metharom, Pat
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656914/
https://ncbi.nlm.nih.gov/pubmed/26569550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.10.009
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