Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes

AIM: Hepatic cytochrome P450 isoenzymes constitute a superfamily of hemoproteins that play a major role in the metabolism of endogenous compounds and in the detoxification of xenobiotic molecules. P450 3A4 is one of the most important forms in human being, and mediates the metabolism of around 70% o...

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Vydáno v:World J Gastroenterol
Hlavní autoři: Yang, Li-Qun, Yu, Wei-Feng, Cao, Yun-Fei, Gong, Bin, Chang, Qing, Yang, Guang-Shun
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2003
Témata:
Liver Cancer
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4656652/
https://ncbi.nlm.nih.gov/pubmed/12970884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v9.i9.1959
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