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Synthesis of an enzyme-dependent prodrug and evaluation of its potential for colon targeting
AIM: To synthesize dexamethasone-succinate-dextran (DSD) conjugate and to evaluate the potentiality of DSD for the treatment of inflammatory bowel diseases. METHODS: Dexamethasone was attached to dextran (average molecular weight = 70400 Dalton) using succinate anhydride in an anhydrous environment...
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| Vydáno v: | World J Gastroenterol |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Baishideng Publishing Group Inc
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4656586/ https://ncbi.nlm.nih.gov/pubmed/12378641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v8.i5.913 |
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