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The Feasibility of Enzyme Targeted Activation for Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine; Cathepsin D as a Potential Targeted Enzym

The improvement of therapeutic efficacy for cancer agents has been a big challenge which includes the increase of tumor selectivity and the reduction of adverse effects at non-tumor sites. In order to achieve those goals, prodrug approaches have been extensively investigated. In this report, the pot...

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Autors principals: Tsume, Yasuhiro, Amidon, Gordon L.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565751/
https://ncbi.nlm.nih.gov/pubmed/22450679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules17043672
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