Antibodies Produced by Clonally Expanded Plasma Cells in Multiple Sclerosis Cerebrospinal Fluid Cause Demyelination of Spinal Cord Explants

B cells are implicated in the etiology of multiple sclerosis (MS). Intrathecal IgG synthesis, cerebrospinal fluid (CSF) oligoclonal bands and lesional IgG deposition suggest a role for antibody-mediated pathology. We examined the binding of IgG1 monoclonal recombinant antibodies (rAbs) derived from...

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Vydáno v:Acta Neuropathol
Hlavní autoři: Blauth, Kevin, Soltys, John, Matschulat, Adeline, Reiter, Cory R., Ritchie, Alanna, Baird, Nicholas L., Bennett, Jeffrey L., Owens, Gregory P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655138/
https://ncbi.nlm.nih.gov/pubmed/26511623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1500-6
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