Antibodies Produced by Clonally Expanded Plasma Cells in Multiple Sclerosis Cerebrospinal Fluid

OBJECTIVE: Intrathecal IgG synthesis, persistence of bands of oligoclonal IgG, and memory B-cell clonal expansion are well-characterized features of the humoral response in multiple sclerosis (MS). Nevertheless, the target antigen of this response remains enigmatic. METHODS: We produced 53 different...

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Main Authors: Owens, Gregory P., Bennett, Jeffrey L., Lassmann, Hans, O’Connor, Kevin C., Ritchie, Alanna M., Shearer, Andrew, Lam, Chiwah, Yu, Xiaoli, Birlea, Marius, DuPree, Cecily, Williamson, R. Anthony, Hafler, David A., Burgoon, Mark P., Gilden, Don
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843543/
https://ncbi.nlm.nih.gov/pubmed/19557869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21641
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