Antibodies Produced by Clonally Expanded Plasma Cells in Multiple Sclerosis Cerebrospinal Fluid

OBJECTIVE: Intrathecal IgG synthesis, persistence of bands of oligoclonal IgG, and memory B-cell clonal expansion are well-characterized features of the humoral response in multiple sclerosis (MS). Nevertheless, the target antigen of this response remains enigmatic. METHODS: We produced 53 different...

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Detalhes bibliográficos
Principais autores: Owens, Gregory P., Bennett, Jeffrey L., Lassmann, Hans, O’Connor, Kevin C., Ritchie, Alanna M., Shearer, Andrew, Lam, Chiwah, Yu, Xiaoli, Birlea, Marius, DuPree, Cecily, Williamson, R. Anthony, Hafler, David A., Burgoon, Mark P., Gilden, Don
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843543/
https://ncbi.nlm.nih.gov/pubmed/19557869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.21641
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