The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T-cell development and leukemia

Pan-NOTCH inhibitors are poorly tolerated in clinical trials because NOTCH signals are crucial for intestinal homeostasis. These inhibitors may also promote cancer as NOTCH can act as a tumor suppressor. We previously reported that the PIAS-like coactivator ZMIZ1 is frequently co-expressed with acti...

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Publicat a:Immunity
Autors principals: Pinnell, Nancy, Yan, Ran, Cho, Hyo Je, Keeley, Theresa, Murai, Marcelo J., Liu, Yiran, Alarcon, Amparo Serna, Qin, Jason, Wang, Qing, Kuick, Rork, Elenitoba-Johnson, Kojo S.J., Maillard, Ivan, Samuelson, Linda C., Cierpicki, Tomasz, Chiang, Mark Y.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654973/
https://ncbi.nlm.nih.gov/pubmed/26522984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.10.007
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