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Neurological disease induced in transgenic mice expressing the env gene of the Cas-Br-E murine retrovirus.

The Cas-Br-E murine leukemia virus induces a spongiform myeloencephalopathy in susceptible mice. We constructed transgenic mice harboring either the viral genome (in a replication-defective form) or only its env gene. Low levels of expression of either transgene resulted in mild neuropathology and/o...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kay, D G, Gravel, C, Pothier, F, Laperrière, A, Robitaille, Y, Jolicoeur, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46547/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8389454/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.10.4538
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