Neurological disease induced in transgenic mice expressing the env gene of the Cas-Br-E murine retrovirus.

The Cas-Br-E murine leukemia virus induces a spongiform myeloencephalopathy in susceptible mice. We constructed transgenic mice harboring either the viral genome (in a replication-defective form) or only its env gene. Low levels of expression of either transgene resulted in mild neuropathology and/o...

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Bibliographic Details
Main Authors: Kay, D G, Gravel, C, Pothier, F, Laperrière, A, Robitaille, Y, Jolicoeur, P
Format: Artigo
Language:Inglês
Published: 1993
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC46547/
https://ncbi.nlm.nih.gov/pubmed/8389454
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