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Turn Nucleation Perturbs Amyloid-β Self-Assembly and Cytotoxicity
The accumulation of senile plaques composed of amyloid-β (Aβ) fibrils is a hallmark of Alzheimer’s disease (AD), although prefibrillar oligomeric species are believed to be the primary neurotoxic congeners in AD pathogenesis. Uncertainty regarding the mechanistic relationship between Aβ oligomer and...
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| Udgivet i: | J Mol Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4654632/ https://ncbi.nlm.nih.gov/pubmed/22326870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.01.055 |
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