The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation

The 5-phosphoinositide phosphatase Sac3, in which loss-of-function mutations are linked to neurodegenerative disorders, forms a stable cytosolic complex with the scaffolding protein ArPIKfyve. The ArPIKfyve-Sac3 heterodimer interacts with the phosphoinositide 5-kinase PIKfyve in a ubiquitous ternary...

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Vydáno v:J Biol Chem
Hlavní autoři: Ikonomov, Ognian C., Sbrissa, Diego, Compton, Lauren M., Kumar, Rita, Tisdale, Ellen J., Chen, Xuequn, Shisheva, Assia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653707/
https://ncbi.nlm.nih.gov/pubmed/26405034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.669929
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