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Mitogen-activated Protein Kinase (MAPK) Activated by Prostaglandin E(2) Phosphorylates Connexin 43 and Closes Osteocytic Hemichannels in Response to Continuous Flow Shear Stress

Cx43 hemichannels serve as a portal for the release of prostaglandins, a critical process in mediating biological responses of mechanical loading on bone formation and remodeling. We have previously observed that fluid flow shear stress (FFSS) opens hemichannels; however, sustained FFSS results in h...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Riquelme, Manuel A., Burra, Sirisha, Kar, Rekha, Lampe, Paul D., Jiang, Jean X.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653687/
https://ncbi.nlm.nih.gov/pubmed/26442583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.683417
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