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High Glucose-induced Retinal Pericyte Apoptosis Depends on Association of GAPDH and Siah1

Diabetic retinopathy (DR) is a leading cause of blindness worldwide, and its prevalence is growing. Current therapies for DR address only the later stages of the disease, are invasive, and have limited effectiveness. Retinal pericyte death is an early pathologic feature of DR. Although it has been o...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Suarez, Sandra, McCollum, Gary W., Jayagopal, Ashwath, Penn, John S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653686/
https://ncbi.nlm.nih.gov/pubmed/26438826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.682385
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