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PKCγ-mediated phosphorylation of GluA1 in the PSD of spinal dorsal horn neurons accompanies neuropathic pain and dephosphorylation by calcineurin is associated with prolonged analgesia

Loss of calcineurin (protein phosphatase 3) activity and protein content in the post-synaptic density (PSD) of spinal dorsal horn neurons was associated with pain behavior following chronic constriction injury (CCI) of the rat sciatic nerve, and intrathecal administration of the phosphatase provided...

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Опубликовано в: :Pain
Главные авторы: Miletic, Gordana, Hermes, Jessie L., Bosscher, Georgia L., Meier, Brenton M., Miletic, Vjekoslav
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653070/
https://ncbi.nlm.nih.gov/pubmed/26270583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000323
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