An increase in glucosylceramide synthase induces Bcl-xL-mediated cell survival in vinorelbine-resistant lung adenocarcinoma cells

Reversing drug resistance with concurrent treatment confers anticancer benefits. In this study, we investigated the potential mechanism of glucosylceramide synthase (GCS)-mediated vinca alkaloid vinorelbine (VNR) resistance in human lung adenocarcinoma cells. Compared with PC14PE6/AS2 (AS2) and CL1-...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Chiu, Wei-Hsin, Su, Wu-Chou, Li, Chia-Ling, Chen, Chia-Ling, Lin, Chiou-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653022/
https://ncbi.nlm.nih.gov/pubmed/26001295
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