Clinical next generation sequencing to identify actionable aberrations in a phase I program

PURPOSE: We determined the frequency of recurrent hotspot mutations in 46 cancer-related genes across tumor histologies in patients with advanced cancer. METHODS: We reviewed data from 500 consecutive patients who underwent genomic profiling on an IRB-approved prospective clinical protocol in the Ph...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Boland, Genevieve M., Piha-Paul, Sarina A., Subbiah, Vivek, Routbort, Mark, Herbrich, Shelley M., Baggerly, Keith, Patel, Keyur P., Brusco, Lauren, Horombe, Chacha, Naing, Aung, Fu, Siqing, Hong, David S., Janku, Filip, Johnson, Amber, Broaddus, Russell, Luthra, Raja, Shaw, Kenna, Mendelsohn, John, Mills, Gordon B., Meric-Bernstam, Funda
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652990/
https://ncbi.nlm.nih.gov/pubmed/26015395
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