Prevalence of MDM2 amplification and coalterations in 523 advanced cancer patients in the MD Anderson phase 1 clinic

BACKGROUND: TP53 is the most commonly mutated gene in cancer and codes for the best studied tumor suppressor, p53. MDM2 is involved in the negative regulation of p53 and itself serves as an oncogene, reported to be overexpressed in several cancer tumor types. In this retrospective study, we assessed...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Dembla, Vikas, Somaiah, Neeta, Barata, Pedro, Hess, Kenneth, Fu, Siqing, Janku, Filip, Karp, Daniel D., Naing, Aung, Piha-Paul, Sarina Anne, Subbiah, Vivek, Tsimberidou, Apostolia M., Shaw, Kenna, Meric-Bernstam, Funda, Hong, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6145698/
https://ncbi.nlm.nih.gov/pubmed/30237864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26075
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