Antiangiogenesis and gene aberration-related therapy may improve overall survival in patients with concurrent KRAS and TP53 hotspot mutant cancer

PURPOSE: Genetic alterations such as activating KRAS and/or inactivating TP53 are thought to be the most common drivers to tumorigenesis. Therefore, we assessed phase I cancer patients with KRAS+/TP53+ mutations. RESULTS: Approximately 8% of patients referred to phase I clinical trials harbored conc...

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Publicado en:Oncotarget
Main Authors: Wang, Zhijie, Piha-Paul, Sarina, Janku, Filip, Subbiah, Vivek, Shi, Naiyi, Gong, Jing, Wathoo, Chetna, Shaw, Kenna, Hess, Kenneth, Broaddus, Russell, Naing, Aung, Hong, David, Tsimberidou, Apostolia M., Karp, Daniel, Yao, James, Meric-Bernstam, Funda, Fu, Siqing
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464912/
https://ncbi.nlm.nih.gov/pubmed/28430579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16840
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