The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have evolved specific eukaryotic factors, one being the BRCA2 double-strand break repair protein. As BRCA2 also protects stalled replication forks and is the FANCD1 member of the Fanc...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: García-Rubio, María L., Pérez-Calero, Carmen, Barroso, Sonia I., Tumini, Emanuela, Herrera-Moyano, Emilia, Rosado, Iván V., Aguilera, Andrés
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652862/
https://ncbi.nlm.nih.gov/pubmed/26584049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005674
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