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A Purification Process for Heparin and Precursor Polysaccharides Using the pH Responsive Behavior of Chitosan

The contamination crisis of 2008 has brought to light several risks associated with use of animal tissue derived heparin. Because the total chemical synthesis of heparin is not feasible, a bioengineered approach has been proposed, relying on recombinant enzymes derived from the heparin/HS biosynthet...

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Библиографические подробности
Опубликовано в: :Biotechnol Prog
Главные авторы: Bhaskar, Ujjwal, Hickey, Anne M., Li, Guoyun, Mundra, Ruchir V., Zhang, Fuming, Fu, Li, Cai, Chao, Ou, Zhimin, Dordick, Jonathan S., Linhardt, Robert J.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652654/
https://ncbi.nlm.nih.gov/pubmed/26147064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btpr.2144
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