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Inhibiting the Protein Ubiquitination Cascade by Ubiquitin-Mimicking Short Peptides
[Image: see text] Short heptapeptides were identified to function as ubiquitin (UB) mimics that are activated by E1 and form thioester conjugates with E1, E2 and HECT type E3 enzymes. The activities (k(cat)/K(1/2)) of E1 with the UB-mimicking peptides are 100–300 fold higher than the equally long pe...
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| Veröffentlicht in: | Org Lett |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4652583/ https://ncbi.nlm.nih.gov/pubmed/23134251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol3027736 |
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