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High-throughput sequencing insights into T-cell receptor repertoire diversity in aging

Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New comput...

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Bibliografske podrobnosti
izdano v:Genome Med
Main Authors: Goronzy, Jörg J., Qi, Qian, Olshen, Richard A., Weyand, Cornelia M.
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652363/
https://ncbi.nlm.nih.gov/pubmed/26582264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0242-3
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