Mutant cohesin affects RNA polymerase II regulation in Cornelia de Lange syndrome

In addition to its role in sister chromatid cohesion, genome stability and integrity, the cohesin complex is involved in gene transcription. Mutations in core cohesin subunits SMC1A, SMC3 and RAD21, or their regulators NIPBL and HDAC8, cause Cornelia de Lange syndrome (CdLS). Recent evidence reveals...

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Vydáno v:Sci Rep
Hlavní autoři: Mannini, Linda, C. Lamaze, Fabien, Cucco, Francesco, Amato, Clelia, Quarantotti, Valentina, Rizzo, Ilaria M, Krantz, Ian D, Bilodeau, Steve, Musio, Antonio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652179/
https://ncbi.nlm.nih.gov/pubmed/26581180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16803
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