Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin

Cornelia de Lange Syndrome (CdLS) is a human developmental disorder caused by mutations that compromise the function of cohesin, a major regulator of 3D genome organization. Cognitive impairment is a universal and as yet unexplained feature of CdLS. We characterize the transcriptional profile of cor...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Weiss, Felix D., Calderon, Lesly, Wang, Yi-Fang, Georgieva, Radina, Guo, Ya, Cvetesic, Nevena, Kaur, Maninder, Dharmalingam, Gopuraja, Krantz, Ian D., Lenhard, Boris, Fisher, Amanda G., Merkenschlager, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8131595/
https://ncbi.nlm.nih.gov/pubmed/34006846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23141-9
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