Prostaglandin E2 activates the mTORC1 pathway through an EP(4)/cAMP/PKA- and EP(1)/Ca(2+)-mediated mechanism in the human pancreatic carcinoma cell line PANC-1

Obesity, a known risk factor for pancreatic cancer, is associated with inflammation and insulin resistance. Proinflammatory prostaglandin E2 (PGE(2)) and elevated insulin-like growth factor type 1 (IGF-1), related to insulin resistance, are shown to play critical roles in pancreatic cancer progressi...

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Vydáno v:Am J Physiol Cell Physiol
Hlavní autoři: Chang, Hui-Hua, Young, Steven H., Sinnett-Smith, James, Chou, Caroline Ei Ne, Moro, Aune, Hertzer, Kathleen M., Hines, Oscar Joe, Rozengurt, Enrique, Eibl, Guido
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652080/
https://ncbi.nlm.nih.gov/pubmed/26310818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00417.2014
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