A heritable missense polymorphism in CDKN2A confers strong risk of childhood acute lymphoblastic leukemia and is preferentially selected during clonal evolution

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in six genes that are associated with childhood acute lymphoblastic leukemia (ALL). A lead SNP was found to occur on chromosome 9p21.3, a region that is deleted in 30% of childhood ALLs, suggesting the pres...

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Publicado no:Cancer Res
Main Authors: Walsh, Kyle M., de Smith, Adam J., Hansen, Helen M., Smirnov, Ivan V., Gonseth, Semira, Endicott, Alyson A., Xiao, Jianqiao, Rice, Terri, Fu, Cecilia H., McCoy, Lucie S., Lachance, Daniel H., Eckel-Passow, Jeanette E., Wiencke, John K., Jenkins, Robert B., Wrensch, Margaret R., Ma, Xiaomei, Metayer, Catherine, Wiemels, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651745/
https://ncbi.nlm.nih.gov/pubmed/26527286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1105
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