A heritable missense polymorphism in CDKN2A confers strong risk of childhood acute lymphoblastic leukemia and is preferentially selected during clonal evolution

Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in six genes that are associated with childhood acute lymphoblastic leukemia (ALL). A lead SNP was found to occur on chromosome 9p21.3, a region that is deleted in 30% of childhood ALLs, suggesting the pres...

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Pubblicato in:Cancer Res
Autori principali: Walsh, Kyle M., de Smith, Adam J., Hansen, Helen M., Smirnov, Ivan V., Gonseth, Semira, Endicott, Alyson A., Xiao, Jianqiao, Rice, Terri, Fu, Cecilia H., McCoy, Lucie S., Lachance, Daniel H., Eckel-Passow, Jeanette E., Wiencke, John K., Jenkins, Robert B., Wrensch, Margaret R., Ma, Xiaomei, Metayer, Catherine, Wiemels, Joseph L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651745/
https://ncbi.nlm.nih.gov/pubmed/26527286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-1105
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