Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA

The extent to which heritable genetic variants can affect tumor development has yet to be fully elucidated. Tumor selection of single nucleotide polymorphism (SNP) risk alleles, a phenomenon called preferential allelic imbalance (PAI), has been demonstrated in some cancer types. We developed a novel...

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Veröffentlicht in:PLoS One
Hauptverfasser: de Smith, Adam J., Walsh, Kyle M., Hansen, Helen M., Endicott, Alyson A., Wiencke, John K., Metayer, Catherine, Wiemels, Joseph L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648491/
https://ncbi.nlm.nih.gov/pubmed/26575185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143343
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