In Oesophageal Squamous Cells, Nitric Oxide Causes S-Nitrosylation of Akt and Blocks SOX2 (Sex Determining Region Y-Box 2) Expression

OBJECTIVE: Barrett’s metaplasia might develop if GORD causes oesophageal squamous cells to convert into columnar cells. Acid and bile exposures upregulate columnar differentiation genes like CDX2 in oesophageal squamous cells, but it is not known if such exposures downregulate squamous differentiati...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Asanuma, Kiyotaka, Huo, Xiaofang, Agoston, Agoston, Zhang, Xi, Yu, Chunhua, Cheng, Edaire, Zhang, Qiuyang, Dunbar, Kerry B., Pham, Thai H., Wang, David H., Iijima, Katsunori, Shimosegawa, Tooru, Odze, Robert D., Spechler, Stuart J., Souza, Rhonda F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651671/
https://ncbi.nlm.nih.gov/pubmed/25986942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-309272
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