A Double Negative Loop Comprising ETV6/RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21)-Positive Acute Lymphoblastic Leukemia

Childhood acute lymphoblastic leukemia (ALL) with t(12;21), which results in expression of the ETV6/RUNX1 fusion gene, is the most common chromosomal lesion in precursor-B (pre-B) ALL. We identified 17 microRNAs that were downregulated in ETV6/RUNX1 (+) compared with ETV6/RUNX1 (−) clinical samples....

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Gepubliceerd in:PLoS One
Hoofdauteurs: Yang, Yung-Li, Yen, Ching-Tzu, Pai, Chen-Hsueh, Chen, Hsuan-Yu, Yu, Sung-Liang, Lin, Chien-Yu, Hu, Chung-Yi, Jou, Shiann-Tarng, Lin, Dong-Tsamn, Lin, Shu-Rung, Lin, Shu-Wha
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651427/
https://ncbi.nlm.nih.gov/pubmed/26580398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142863
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