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Activity after Site-Directed Mutagenesis of CD59 on Complement-Mediated Cytolysis
CD59 may inhibit the cytolytic activity of complement by binding to C8/C9 and protect host cell membranes against homologous membrane attack complex (MAC). However, CD59 is widely overexpressed on tumor cells, which has been implicated in tumorigenesis. The active site of CD59 relative to MAC is sti...
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| Veröffentlicht in: | Cell Mol Immunol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4651242/ https://ncbi.nlm.nih.gov/pubmed/18445344 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2008.17 |
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