Activity after Site-Directed Mutagenesis of CD59 on Complement-Mediated Cytolysis

CD59 may inhibit the cytolytic activity of complement by binding to C8/C9 and protect host cell membranes against homologous membrane attack complex (MAC). However, CD59 is widely overexpressed on tumor cells, which has been implicated in tumorigenesis. The active site of CD59 relative to MAC is sti...

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Detaylı Bibliyografya
Yayımlandı:Cell Mol Immunol
Asıl Yazarlar: Zhu, Xinhong, Gao, Meihua, Ren, Shurong, Wang, Qiubo, Lin, Cunzhi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2008
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651242/
https://ncbi.nlm.nih.gov/pubmed/18445344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2008.17
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