Transgene-host cell interactions mediate significant influences on the production, stability, and function of recombinant canine FVIII

Recombinant FVIII manufacturing is characterized by poor product stability and low yields. Codon-optimization of transgenes accelerates translation by exploiting the synonymous codon usage bias of a species. However, this can alter the performance of the final product. Additionally, the effects of t...

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Библиографические подробности
Опубликовано в: :Mol Ther Methods Clin Dev
Главные авторы: Crawford, Bredon, Ozelo, Margareth C, Ogiwara, Kenichi, Ahlin, James, Albanez, Silvia, Hegadorn, Carol, Harpell, Lori, Hough, Christine, Lillicrap, David
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650998/
https://ncbi.nlm.nih.gov/pubmed/26636112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2015.33
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