Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

We previously reported that IL-2 deprivation induced acid sphingomyelinase-mediated (ASM-mediated) ceramide elevation and apoptosis in an NK/T lymphoma cell line KHYG-1. However, the molecular mechanism of ASM–ceramide-mediated apoptosis during IL-2 deprivation is poorly understood. Here, we showed...

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Publicado en:Cell Death Dis
Autores principales: Taniguchi, M, Ogiso, H, Takeuchi, T, Kitatani, K, Umehara, H, Okazaki, T
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650549/
https://ncbi.nlm.nih.gov/pubmed/25855965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.82
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