Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and incurable disease. Poor prognosis is due to multiple reasons, including acquisition of resistance to gemcitabine, the first line chemotherapeutic approach. Thus, there is a strong need for novel therapies, targeting more directly the molec...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Calabretta, Sara, Bielli, Pamela, Passacantilli, Ilaria, Pilozzi, Emanuela, Fendrich, Volker, Capurso, Gabriele, Delle Fave, Gianfranco, Sette, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650269/
https://ncbi.nlm.nih.gov/pubmed/26234680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.270
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados