Alternative polyadenylation of ZEB1 promotes its translation during genotoxic stress in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extremely poor prognosis. The standard chemotherapeutic drug, gemcitabine, does not offer significant improvements for PDAC management due to the rapid acquisition of drug resistance by patients. Recent evidence indicates that epithelial-to...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Passacantilli, Ilaria, Panzeri, Valentina, Bielli, Pamela, Farini, Donatella, Pilozzi, Emanuela, Fave, Gianfranco Delle, Capurso, Gabriele, Sette, Claudio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5775412/
https://ncbi.nlm.nih.gov/pubmed/29120411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.562
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