Analyzing Th17 cell differentiation dynamics using a novel integrative modeling framework for time-course RNA sequencing data

BACKGROUND: The differentiation of naive CD 4(+) helper T (Th) cells into effector Th17 cells is steered by extracellular cytokines that activate and control the lineage specific transcriptional program. While the inducing cytokine signals and core transcription factors driving the differentiation t...

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Foilsithe in:BMC Syst Biol
Main Authors: Intosalmi, Jukka, Ahlfors, Helena, Rautio, Sini, Mannerstöm, Henrik, Chen, Zhi Jane, Lahesmaa, Riitta, Stockinger, Brigitta, Lähdesmäki, Harri
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650136/
https://ncbi.nlm.nih.gov/pubmed/26578352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-015-0223-6
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