Suppression of BRCA1 sensitizes cells to proteasome inhibitors

BRCA1 is a multifunctional protein best known for its role in DNA repair and association with breast and ovarian cancers. To uncover novel biologically significant molecular functions of BRCA1, we tested a panel of 198 approved and experimental drugs to inhibit growth of MDA-MB-231 breast cancer cel...

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Foilsithe in:Cell Death Dis
Main Authors: Gu, Y, Bouwman, P, Greco, D, Saarela, J, Yadav, B, Jonkers, J, Kuznetsov, S G
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2014
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649846/
https://ncbi.nlm.nih.gov/pubmed/25522274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.537
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